increased susceptibility to weight gain Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake (Mammalian Phenotype Ontology, MP_0005455)
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87 gene mutations causing the increased susceptibility to weight gain phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRA1B adrenoceptor alpha 1B
ADRB3 adrenoceptor beta 3
ALMS1 Alstrom syndrome protein 1
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ASIP agouti signaling protein
ATXN2 ataxin 2
BBS12 Bardet-Biedl syndrome 12
BBS4 Bardet-Biedl syndrome 4
BCO1 beta-carotene oxygenase 1
BDNF brain-derived neurotrophic factor
CARTPT CART prepropeptide
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CELF4 CUGBP, Elav-like family member 4
CLOCK clock circadian regulator
CPT1C carnitine palmitoyltransferase 1C
CSPG4 chondroitin sulfate proteoglycan 4
CTF1 cardiotrophin 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DRD3 dopamine receptor D3
FABP2 fatty acid binding protein 2, intestinal
FFAR4 free fatty acid receptor 4
FOXO1 forkhead box O1
FTO fat mass and obesity associated
GHRHR growth hormone releasing hormone receptor
GPBAR1 G protein-coupled bile acid receptor 1
GPR26 G protein-coupled receptor 26
HCRT hypocretin (orexin) neuropeptide precursor
HDC histidine decarboxylase
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
LEPR leptin receptor
LTA lymphotoxin alpha
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MMP19 matrix metallopeptidase 19
MRAP2 melanocortin 2 receptor accessory protein 2
NCOR2 nuclear receptor corepressor 2
NHLH2 nescient helix loop helix 2
NMUR2 neuromedin U receptor 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPBWR1 neuropeptides B/W receptor 1
NPY5R neuropeptide Y receptor Y5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OMA1 OMA1 zinc metallopeptidase
OSMR oncostatin M receptor
PCSK1 proprotein convertase subtilisin/kexin type 1
PHB2 prohibitin 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYY peptide YY
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SELM selenoprotein M
SIM1 single-minded family bHLH transcription factor 1
SIRT3 sirtuin 3
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SQSTM1 sequestosome 1
SST somatostatin
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TP53INP1 tumor protein p53 inducible nuclear protein 1
TUB tubby bipartite transcription factor
UBB ubiquitin B
WRN Werner syndrome, RecQ helicase-like
ZC3H4 zinc finger CCCH-type containing 4
ZEB1 zinc finger E-box binding homeobox 1
ZMPSTE24 zinc metallopeptidase STE24