increased susceptibility to viral infection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus (Mammalian Phenotype Ontology, MP_0002418)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002418
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Genes

101 gene mutations causing the increased susceptibility to viral infection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
AIM2 absent in melanoma 2
AP3B1 adaptor-related protein complex 3, beta 1 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF2 activating transcription factor 2
BCL2L12 BCL2-like 12 (proline rich)
BST2 bone marrow stromal cell antigen 2
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD207 CD207 molecule, langerin
CD4 CD4 molecule
CD70 CD70 molecule
CD8A CD8a molecule
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DICER1 dicer 1, ribonuclease type III
DTNBP1 dystrobrevin binding protein 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FLT3 fms-related tyrosine kinase 3
FOXN1 forkhead box N1
GZMM granzyme M (lymphocyte met-ase 1)
HLA-E major histocompatibility complex, class I, E
HPS5 Hermansky-Pudlak syndrome 5
IFIH1 interferon induced with helicase C domain 1
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM3 interferon induced transmembrane protein 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL15 interleukin 15
IL2 interleukin 2
IL34 interleukin 34
IL6 interleukin 6
ILF3 interleukin enhancer binding factor 3, 90kDa
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF4 interferon regulatory factor 4
IRF7 interferon regulatory factor 7
IRF8 interferon regulatory factor 8
IRF9 interferon regulatory factor 9
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
LTA lymphotoxin alpha
LYST lysosomal trafficking regulator
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MST1R macrophage stimulating 1 receptor
MX1 MX dynamin-like GTPase 1
MYD88 myeloid differentiation primary response 88
NCR1 natural cytotoxicity triggering receptor 1
NFE2 nuclear factor, erythroid 2
NLRX1 NLR family member X1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRF1 perforin 1 (pore forming protein)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
RAB27A RAB27A, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SAMD9L sterile alpha motif domain containing 9-like
SAMHD1 SAM domain and HD domain 1
SARM1 sterile alpha and TIR motif containing 1
SELK selenoprotein K
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SFTPA1 surfactant protein A1
SFTPD surfactant protein D
SH2D1A SH2 domain containing 1A
SLAMF1 signaling lymphocytic activation molecule family member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STX11 syntaxin 11
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
XPR1 xenotropic and polytropic retrovirus receptor 1