increased susceptibility to parasitic infection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites (Mammalian Phenotype Ontology, MP_0005027)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005027
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Genes

85 gene mutations causing the increased susceptibility to parasitic infection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
APOE apolipoprotein E
AQP4 aquaporin 4
BATF2 basic leucine zipper transcription factor, ATF-like 2
BCL3 B-cell CLL/lymphoma 3
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CIITA class II, major histocompatibility complex, transactivator
CLEC10A C-type lectin domain family 10, member A
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR2 chemokine (C-X-C motif) receptor 2
DUSP4 dual specificity phosphatase 4
EBI3 Epstein-Barr virus induced 3
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLT3LG fms-related tyrosine kinase 3 ligand
GBP2 guanylate binding protein 2, interferon-inducible
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL17RB interleukin 17 receptor B
IL18 interleukin 18
IL25 interleukin 25
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL3 interleukin 3
IL31RA interleukin 31 receptor A
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IL9 interleukin 9
ITGB7 integrin, beta 7
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JCHAIN joining chain of multimeric IgA and IgM
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LYST lysosomal trafficking regulator
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOS2 nitric oxide synthase 2, inducible
OTC ornithine carbamoyltransferase
PDCD1LG2 programmed cell death 1 ligand 2
PIGR polymeric immunoglobulin receptor
PLAU plasminogen activator, urokinase
POU2AF1 POU class 2 associating factor 1
PRF1 perforin 1 (pore forming protein)
PTAFR platelet-activating factor receptor
RGS16 regulator of G-protein signaling 16
SDC1 syndecan 1
SEPP1 selenoprotein P, plasma, 1
SH2D1A SH2 domain containing 1A
SLAMF1 signaling lymphocytic activation molecule family member 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TBX21 T-box 21
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TPSAB1 tryptase alpha/beta 1
TXK TXK tyrosine kinase
TYK2 tyrosine kinase 2
ZBTB46 zinc finger and BTB domain containing 46