increased susceptibility to bacterial infection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria (Mammalian Phenotype Ontology, MP_0002412)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002412
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Genes

259 gene mutations causing the increased susceptibility to bacterial infection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHR aryl hydrocarbon receptor
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
ANK1 ankyrin 1, erythrocytic
ANXA6 annexin A6
APCS amyloid P component, serum
APOE apolipoprotein E
ASGR1 asialoglycoprotein receptor 1
ASGR2 asialoglycoprotein receptor 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASTE1 asteroid homolog 1 (Drosophila)
ATF2 activating transcription factor 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BPIFA1 BPI fold containing family A, member 1
BTK Bruton agammaglobulinemia tyrosine kinase
C17ORF62 chromosome 17 open reading frame 62
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C5 complement component 5
C5AR1 complement component 5a receptor 1
CAMP cathelicidin antimicrobial peptide
CAPG capping protein (actin filament), gelsolin-like
CARD9 caspase recruitment domain family, member 9
CAV1 caveolin 1, caveolae protein, 22kDa
CBY1 chibby homolog 1 (Drosophila)
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD1D CD1d molecule
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CD5L CD5 molecule-like
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CERK ceramide kinase
CFAP36 cilia and flagella associated protein 36
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLEC4D C-type lectin domain family 4, member D
CLIC4 chloride intracellular channel 4
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRTAM cytotoxic and regulatory T cell molecule
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CUX1 cut-like homeobox 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DAAM2 dishevelled associated activator of morphogenesis 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCLRE1A DNA cross-link repair 1A
DEFB1 defensin, beta 1
DLG2 discs, large homolog 2 (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
E2F4 E2F transcription factor 4, p107/p130-binding
ELANE elastase, neutrophil expressed
FAM134C family with sequence similarity 134, member C
FAM73B family with sequence similarity 73, member B
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO7 F-box protein 7
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCMR Fc fragment of IgM receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FES FES proto-oncogene, tyrosine kinase
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
FPR1 formyl peptide receptor 1
G6PC3 glucose 6 phosphatase, catalytic, 3
GBA2 glucosidase, beta (bile acid) 2
GBP3 guanylate binding protein 3
GBP5 guanylate binding protein 5
GIF gastric intrinsic factor (vitamin B synthesis)
GPC3 glypican 3
GPR15 G protein-coupled receptor 15
GRN granulin
GSK3A glycogen synthase kinase 3 alpha
GSTA4 glutathione S-transferase alpha 4
HAMP hepcidin antimicrobial peptide
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPS5 Hermansky-Pudlak syndrome 5
HSF1 heat shock transcription factor 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNE interferon, epsilon
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFT80 intraflagellar transport 80
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IL12B interleukin 12B
IL17A interleukin 17A
IL17F interleukin 17F
IL17RE interleukin 17 receptor E
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL23A interleukin 23, alpha subunit p19
IL27RA interleukin 27 receptor, alpha
IL6 interleukin 6
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITGAD integrin, alpha D
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK3 Janus kinase 3
JAM3 junctional adhesion molecule 3
JCHAIN joining chain of multimeric IgA and IgM
JDP2 Jun dimerization protein 2
KIF1C kinesin family member 1C
KMT2E lysine (K)-specific methyltransferase 2E
KPTN kaptin (actin binding protein)
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LMNB2 lamin B2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY96 lymphocyte antigen 96
LYST lysosomal trafficking regulator
MAP2K3 mitogen-activated protein kinase kinase 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH5 membrane-associated ring finger (C3HC4) 5
MARCO macrophage receptor with collagenous structure
MDN1 MDN1, midasin homolog (yeast)
MIER1 mesoderm induction early response 1, transcriptional regulator
MIR155 microRNA 155
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MSR1 macrophage scavenger receptor 1
MST1R macrophage stimulating 1 receptor
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NCAPH non-SMC condensin I complex, subunit H
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOA3 nuclear receptor coactivator 3
NCR1 natural cytotoxicity triggering receptor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
OCA2 oculocutaneous albinism II
OLFM4 olfactomedin 4
PADI4 peptidyl arginine deiminase, type IV
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX3 peroxisomal biogenesis factor 3
PGLYRP1 peptidoglycan recognition protein 1
PIAS1 protein inhibitor of activated STAT, 1
PIGR polymeric immunoglobulin receptor
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PILRA paired immunoglobin-like type 2 receptor alpha
PKLR pyruvate kinase, liver and RBC
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PML promyelocytic leukemia
PON2 paraoxonase 2
PRF1 perforin 1 (pore forming protein)
PRKCE protein kinase C, epsilon
PRMT2 protein arginine methyltransferase 2
PTX3 pentraxin 3, long
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAG2 recombination activating gene 2
RASA4 RAS p21 protein activator 4
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIF1 replication timing regulatory factor 1
RIPK4 receptor-interacting serine-threonine kinase 4
RNASEH2B ribonuclease H2, subunit B
RORC RAR-related orphan receptor C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA1 surfactant protein A1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLAMF6 SLAM family member 6
SLAMF8 SLAM family member 8
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SLPI secretory leukocyte peptidase inhibitor
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SPTA1 spectrin, alpha, erythrocytic 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOM1L2 target of myb1-like 2 (chicken)
TP73 tumor protein p73
TPI1 triosephosphate isomerase 1
TPSAB1 tryptase alpha/beta 1
TRADD TNFRSF1A-associated via death domain
TRAF3IP3 TRAF3 interacting protein 3
TREX1 three prime repair exonuclease 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3
UBD ubiquitin D
UMOD uromodulin
UNC93B1 unc-93 homolog B1 (C. elegans)
USP18 ubiquitin specific peptidase 18
VSIG4 V-set and immunoglobulin domain containing 4
VWF von Willebrand factor