increased susceptibility to autoimmune disorder Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides (Mammalian Phenotype Ontology, MP_0005350)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005350
Similar Terms
Downloads & Tools

Genes

116 gene mutations causing the increased susceptibility to autoimmune disorder phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
AIRE autoimmune regulator
APOE apolipoprotein E
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTLA B and T lymphocyte associated
C1QTNF3 C1q and tumor necrosis factor related protein 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD200 CD200 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CD38 CD38 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CNTF ciliary neurotrophic factor
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYTL1 cytokine-like 1
DNASE1 deoxyribonuclease I
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
ECM1 extracellular matrix protein 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FFAR2 free fatty acid receptor 2
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
HCST hematopoietic cell signal transducer
HLA-E major histocompatibility complex, class I, E
HR hair growth associated
HRH3 histamine receptor H3
ICOS inducible T-cell co-stimulator
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL25 interleukin 25
IL27 interleukin 27
IL27RA interleukin 27 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL6ST interleukin 6 signal transducer
IL9R interleukin 9 receptor
INS insulin
LAT linker for activation of T cells
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS9B lectin, galactoside-binding, soluble, 9B
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK3 mitogen-activated protein kinase 3
MBP myelin basic protein
MIR140 microRNA 140
MMP2 matrix metallopeptidase 2
MOG myelin oligodendrocyte glycoprotein
MPO myeloperoxidase
MR1 major histocompatibility complex, class I-related
MTA2 metastasis associated 1 family, member 2
MTUS1 microtubule associated tumor suppressor 1
MUC19 mucin 19, oligomeric
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PGAP3 post-GPI attachment to proteins 3
PGLYRP1 peptidoglycan recognition protein 1
POLB polymerase (DNA directed), beta
PPARG peroxisome proliferator-activated receptor gamma
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCARF1 scavenger receptor class F, member 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIT1 signaling threshold regulating transmembrane adaptor 1
SOCS3 suppressor of cytokine signaling 3
SOD3 superoxide dismutase 3, extracellular
SYT7 synaptotagmin VII
TBC1D10C TBC1 domain family, member 10C
TIGIT T cell immunoreceptor with Ig and ITIM domains
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TREX1 three prime repair exonuclease 1
TUSC2 tumor suppressor candidate 2
USP25 ubiquitin specific peptidase 25
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H12D zinc finger CCCH-type containing 12D