increased skin tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0010300)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010300
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Genes

41 gene mutations causing the increased skin tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKB aurora kinase B
CD34 CD34 molecule
CDK11A cyclin-dependent kinase 11A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHUK conserved helix-loop-helix ubiquitous kinase
CYLD cylindromatosis (turban tumor syndrome)
EAF2 ELL associated factor 2
EGR1 early growth response 1
ERCC2 excision repair cross-complementation group 2
ERRFI1 ERBB receptor feedback inhibitor 1
GRM1 glutamate receptor, metabotropic 1
GSTP1 glutathione S-transferase pi 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT9 keratin 9, type I
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PAQR3 progestin and adipoQ receptor family member III
PLCD1 phospholipase C, delta 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLH polymerase (DNA directed), eta
PPARD peroxisome proliferator-activated receptor delta
PRKCA protein kinase C, alpha
PRKCH protein kinase C, eta
PTCH1 patched 1
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SFN stratifin
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
XPA xeroderma pigmentosum, complementation group A