increased sarcoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0002032)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002032
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Genes

81 gene mutations causing the increased sarcoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTB actin, beta
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
BECN1 beclin 1, autophagy related
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CREBBP CREB binding protein
CUL9 cullin 9
CYTIP cytohesin 1 interacting protein
DCLRE1A DNA cross-link repair 1A
DGKD diacylglycerol kinase, delta 130kDa
DKC1 dyskeratosis congenita 1, dyskerin
E2F1 E2F transcription factor 1
EXO1 exonuclease 1
FASLG Fas ligand (TNF superfamily, member 6)
FBXO4 F-box protein 4
FEN1 flap structure-specific endonuclease 1
FLT3 fms-related tyrosine kinase 3
FOXN1 forkhead box N1
FOXO3 forkhead box O3
GPX7 glutathione peroxidase 7
HIC1 hypermethylated in cancer 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
ING2 inhibitor of growth family, member 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LATS1 large tumor suppressor kinase 1
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP8 matrix metallopeptidase 8
MSH2 mutS homolog 2
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
RECQL4 RecQ protein-like 4
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RGPD1 RANBP2-like and GRIP domain containing 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
S100A4 S100 calcium binding protein A4
SAV1 salvador family WW domain containing protein 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SSBP2 single-stranded DNA binding protein 2
STAG1 stromal antigen 1
STK4 serine/threonine kinase 4
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TRIM62 tripartite motif containing 62
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUSC2 tumor suppressor candidate 2
USP44 ubiquitin specific peptidase 44
WIF1 WNT inhibitory factor 1
WWOX WW domain containing oxidoreductase