increased reproductive system tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in the reproductive system in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010287)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010287
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Genes

46 gene mutations causing the increased reproductive system tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACPP acid phosphatase, prostate
AMHR2 anti-Mullerian hormone receptor, type II
AR androgen receptor
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
CABLES1 Cdk5 and Abl enzyme substrate 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CUL9 cullin 9
DCLRE1A DNA cross-link repair 1A
DND1 DND microRNA-mediated repression inhibitor 1
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
FBXO4 F-box protein 4
FOXO3 forkhead box O3
FSHR follicle stimulating hormone receptor
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HELQ helicase, POLQ-like
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INHA inhibin, alpha
KITLG KIT ligand
LATS1 large tumor suppressor kinase 1
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
NBN nibrin
NKX3-1 NK3 homeobox 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PTEN phosphatase and tensin homolog
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RINT1 RAD50 interactor 1
SAV1 salvador family WW domain containing protein 1
SF1 splicing factor 1
SIRT2 sirtuin 2
SMAD4 SMAD family member 4
SPTBN1 spectrin, beta, non-erythrocytic 1
STK11 serine/threonine kinase 11
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TSC1 tuberous sclerosis 1
ZFHX3 zinc finger homeobox 3