increased pro-b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs (Mammalian Phenotype Ontology, MP_0008186)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008186
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Genes

30 gene mutations causing the increased pro-b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDH17 cadherin 17, LI cadherin (liver-intestine)
CYLD cylindromatosis (turban tumor syndrome)
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXO7 F-box protein 7
FES FES proto-oncogene, tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FNIP1 folliculin interacting protein 1
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2 interleukin 2
KMT2A lysine (K)-specific methyltransferase 2A
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PGM3 phosphoglucomutase 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
TAC4 tachykinin 4 (hemokinin)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TSHR thyroid stimulating hormone receptor