increased plasma cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin (Mammalian Phenotype Ontology, MP_0008097)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008097
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Genes

25 gene mutations causing the increased plasma cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
ICOS inducible T-cell co-stimulator
IGHM immunoglobulin heavy constant mu
IL10 interleukin 10
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
JAK1 Janus kinase 1
LAT linker for activation of T cells
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
TANK TRAF family member-associated NFKB activator
TNIP1 TNFAIP3 interacting protein 1
WAS Wiskott-Aldrich syndrome
ZC3H12A zinc finger CCCH-type containing 12A