increased physiological sensitivity to xenobiotic Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the dose or concentration of a foreign compound required to induce a specific level of physiological response (Mammalian Phenotype Ontology, MP_0008873)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008873
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Genes

194 gene mutations causing the increased physiological sensitivity to xenobiotic phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACHE acetylcholinesterase (Yt blood group)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGTR2 angiotensin II receptor, type 2
AGXT alanine-glyoxylate aminotransferase
AHR aryl hydrocarbon receptor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
APC adenomatous polyposis coli
APOD apolipoprotein D
AQP5 aquaporin 5
ATF6 activating transcription factor 6
ATG4C autophagy related 4C, cysteine peptidase
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCHE butyrylcholinesterase
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CASC1 cancer susceptibility candidate 1
CAST calpastatin
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCR2 chemokine (C-C motif) receptor 2
CD226 CD226 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHRM1 cholinergic receptor, muscarinic 1
CNR1 cannabinoid receptor 1 (brain)
COL5A3 collagen, type V, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CPB2 carboxypeptidase B2 (plasma)
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTH cystathionine gamma-lyase
CUL9 cullin 9
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYGB cytoglobin
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DNAH11 dynein, axonemal, heavy chain 11
DRD2 dopamine receptor D2
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPHA2 EPH receptor A2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
EREG epiregulin
ERRFI1 ERBB receptor feedback inhibitor 1
FHIT fragile histidine triad
FLCN folliculin
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
FPR2 formyl peptide receptor 2
FRZB frizzled-related protein
FST follistatin
GAL galanin/GMAP prepropeptide
GAST gastrin
GCLM glutamate-cysteine ligase, modifier subunit
GLP2R glucagon-like peptide 2 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR26 G protein-coupled receptor 26
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRN granulin
GSTA3 glutathione S-transferase alpha 3
HINT1 histidine triad nucleotide binding protein 1
HPCA hippocalcin
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTRA2 HtrA serine peptidase 2
HYOU1 hypoxia up-regulated 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IL10 interleukin 10
IL12A interleukin 12A
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL36RN interleukin 36 receptor antagonist
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IP6K2 inositol hexakisphosphate kinase 2
IRF1 interferon regulatory factor 1
IVNS1ABP influenza virus NS1A binding protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF10 Kruppel-like factor 10
LYNX1 Ly6/neurotoxin 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MGMT O-6-methylguanine-DNA methyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR22 microRNA 22
MIR451A microRNA 451a
MPG N-methylpurine-DNA glycosylase
MPO myeloperoxidase
MSH2 mutS homolog 2
MXI1 MAX interactor 1, dimerization protein
MYD88 myeloid differentiation primary response 88
MYH11 myosin, heavy chain 11, smooth muscle
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NFE2L2 nuclear factor, erythroid 2-like 2
NIT1 nitrilase 1
NLRP12 NLR family, pyrin domain containing 12
NLRP6 NLR family, pyrin domain containing 6
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS4 neuronal PAS domain protein 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGG1 8-oxoguanine DNA glycosylase
PAQR3 progestin and adipoQ receptor family member III
PARK7 parkinson protein 7
PDC phosducin
PLCL1 phospholipase C-like 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRF1 perforin 1 (pore forming protein)
PRIMA1 proline rich membrane anchor 1
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSEN1 presenilin 1
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRT protein tyrosine phosphatase, receptor type, T
RAE1 ribonucleic acid export 1
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGPD1 RANBP2-like and GRIP domain containing 1
RHOB ras homolog family member B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RYR2 ryanodine receptor 2 (cardiac)
SDC4 syndecan 4
SF1 splicing factor 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
STK11 serine/threonine kinase 11
TAAR1 trace amine associated receptor 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS2 thrombospondin 2
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP73 tumor protein p73
TREX2 three prime repair exonuclease 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC1 tuberous sclerosis 1
TYROBP TYRO protein tyrosine kinase binding protein
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UIMC1 ubiquitin interaction motif containing 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A