increased pancreatic alpha cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the number of the cells of the pancreas that secrete glucagon (Mammalian Phenotype Ontology, MP_0009176)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009176
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Genes

14 gene mutations causing the increased pancreatic alpha cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
G6PC3 glucose 6 phosphatase, catalytic, 3
GCGR glucagon receptor
GDF11 growth differentiation factor 11
INS insulin
LEPR leptin receptor
MIR375 microRNA 375
NKX2-2 NK2 homeobox 2
PDX1 pancreatic and duodenal homeobox 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RIMS2 regulating synaptic membrane exocytosis 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)