increased osteoclast cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue (Mammalian Phenotype Ontology, MP_0004984)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004984
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Genes

54 gene mutations causing the increased osteoclast cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
BGLAP bone gamma-carboxyglutamate (gla) protein
CARTPT CART prepropeptide
CCL13 chemokine (C-C motif) ligand 13
CLCN7 chloride channel, voltage-sensitive 7
CLDN18 claudin 18
CLEC2D C-type lectin domain family 2, member D
CNOT3 CCR4-NOT transcription complex, subunit 3
CTSK cathepsin K
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
EBF1 early B-cell factor 1
EGR1 early growth response 1
ESR1 estrogen receptor 1
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBLIM1 filamin binding LIM protein 1
FGFR3 fibroblast growth factor receptor 3
FOSL2 FOS-like antigen 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GGT1 gamma-glutamyltransferase 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR55 G protein-coupled receptor 55
HSPG2 heparan sulfate proteoglycan 2
IAPP islet amyloid polypeptide
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK3 interleukin-1 receptor-associated kinase 3
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LRRK1 leucine-rich repeat kinase 1
MITF microphthalmia-associated transcription factor
NCOR2 nuclear receptor corepressor 2
NFE2 nuclear factor, erythroid 2
NLRP3 NLR family, pyrin domain containing 3
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
POSTN periostin, osteoblast specific factor
SGPL1 sphingosine-1-phosphate lyase 1
SH3BP2 SH3-domain binding protein 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THRB thyroid hormone receptor, beta
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOB2 transducer of ERBB2, 2
TRPV5 transient receptor potential cation channel, subfamily V, member 5
VCP valosin containing protein
WDR1 WD repeat domain 1