increased number of pulmonary neuroendocrine bodies Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors (Mammalian Phenotype Ontology, MP_0010919)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010919
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Genes

3 gene mutations causing the increased number of pulmonary neuroendocrine bodies phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
FBN1 fibrillin 1
HES1 hes family bHLH transcription factor 1
NEUROD1 neuronal differentiation 1