increased nucleated erythrocyte cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells (Mammalian Phenotype Ontology, MP_0009395)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009395
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Genes

39 gene mutations causing the increased nucleated erythrocyte cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ANK1 ankyrin 1, erythrocytic
CAPNS1 calpain, small subunit 1
CCBE1 collagen and calcium binding EGF domains 1
DNASE2 deoxyribonuclease II, lysosomal
DPH1 diphthamide biosynthesis 1
E2F4 E2F transcription factor 4, p107/p130-binding
FERMT3 fermitin family member 3
IGF2R insulin-like growth factor 2 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KLF1 Kruppel-like factor 1 (erythroid)
KLF2 Kruppel-like factor 2
LIG1 ligase I, DNA, ATP-dependent
MAEA macrophage erythroblast attacher
MED1 mediator complex subunit 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NFE2L1 nuclear factor, erythroid 2-like 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PKLR pyruvate kinase, liver and RBC
PKNOX1 PBX/knotted 1 homeobox 1
PLVAP plasmalemma vesicle associated protein
RB1 retinoblastoma 1
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SIN3B SIN3 transcription regulator family member B
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOCS3 suppressor of cytokine signaling 3
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
TMOD3 tropomodulin 3 (ubiquitous)
TTC7A tetratricopeptide repeat domain 7A
ZFP36L2 ZFP36 ring finger protein-like 2