increased nk cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells (Mammalian Phenotype Ontology, MP_0008044)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008044
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Genes

34 gene mutations causing the increased nk cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARID4A AT rich interactive domain 4A (RBP1-like)
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CXCR4 chemokine (C-X-C motif) receptor 4
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
E2F4 E2F transcription factor 4, p107/p130-binding
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FAS Fas cell surface death receptor
FOXO3 forkhead box O3
IDE insulin-degrading enzyme
IL18 interleukin 18
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIMK2 LIM domain kinase 2
MIER1 mesoderm induction early response 1, transcriptional regulator
NCR1 natural cytotoxicity triggering receptor 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RHBDD3 rhomboid domain containing 3
RHOH ras homolog family member H
RNASE10 ribonuclease, RNase A family, 10 (non-active)
SETDB1 SET domain, bifurcated 1
SMS spermine synthase
SPNS2 spinster homolog 2 (Drosophila)
TBX21 T-box 21
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
XPA xeroderma pigmentosum, complementation group A
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF205 zinc finger protein 205