increased nervous system tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in the nervous system in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010281)
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28 gene mutations causing the increased nervous system tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIP aryl hydrocarbon receptor interacting protein
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CUL9 cullin 9
CXCR6 chemokine (C-X-C motif) receptor 6
DRD2 dopamine receptor D2
FOXO3 forkhead box O3
HELQ helicase, POLQ-like
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
LIG4 ligase IV, DNA, ATP-dependent
MEN1 multiple endocrine neoplasia I
MSH2 mutS homolog 2
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
POMC proopiomelanocortin
PRDM2 PR domain containing 2, with ZNF domain
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRL prolactin
PTCH1 patched 1
RB1 retinoblastoma 1
RET ret proto-oncogene
RINT1 RAD50 interactor 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SPTBN1 spectrin, beta, non-erythrocytic 1
THRB thyroid hormone receptor, beta
TP53 tumor protein p53