increased megakaryocyte cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm (Mammalian Phenotype Ontology, MP_0008254)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008254
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Genes

38 gene mutations causing the increased megakaryocyte cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ARNTL aryl hydrocarbon receptor nuclear translocator-like
BCL2L1 BCL2-like 1
C6ORF25 chromosome 6 open reading frame 25
CHD2 chromodomain helicase DNA binding protein 2
CREBBP CREB binding protein
DCC DCC netrin 1 receptor
DIDO1 death inducer-obliterator 1
EP300 E1A binding protein p300
ESR2 estrogen receptor 2 (ER beta)
FLT3 fms-related tyrosine kinase 3
GATA1 GATA binding protein 1 (globin transcription factor 1)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NBEAL2 neurobeachin-like 2
NCOR2 nuclear receptor corepressor 2
NFE2 nuclear factor, erythroid 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PROS1 protein S (alpha)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RASA3 RAS p21 protein activator 3
RB1 retinoblastoma 1
SH2B3 SH2B adaptor protein 3
SIRPA signal-regulatory protein alpha
SOS1 son of sevenless homolog 1 (Drosophila)
SPRED2 sprouty-related, EVH1 domain containing 2
STIM1 stromal interaction molecule 1
T T, brachyury homolog (mouse)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
VASP vasodilator-stimulated phosphoprotein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR1 WD repeat domain 1