increased mature b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex (Mammalian Phenotype Ontology, MP_0008210)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008210
Similar Terms
Downloads & Tools

Genes

94 gene mutations causing the increased mature b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
AIRE autoimmune regulator
APOE apolipoprotein E
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
AVPR1A arginine vasopressin receptor 1A
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BMF Bcl2 modifying factor
CCR6 chemokine (C-C motif) receptor 6
CD22 CD22 molecule
CD72 CD72 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DLK1 delta-like 1 homolog (Drosophila)
EPS15 epidermal growth factor receptor pathway substrate 15
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GAPT GRB2-binding adaptor protein, transmembrane
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HAX1 HCLS1 associated protein X-1
ICOS inducible T-cell co-stimulator
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IRF8 interferon regulatory factor 8
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MED18 mediator complex subunit 18
MIR150 microRNA 150
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR1D2 nuclear receptor subfamily 1, group D, member 2
PARP14 poly (ADP-ribose) polymerase family, member 14
PDCD1 programmed cell death 1
PEX3 peroxisomal biogenesis factor 3
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
S1PR2 sphingosine-1-phosphate receptor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEPT8 septin 8
SH2B2 SH2B adaptor protein 2
SH3BP2 SH3-domain binding protein 2
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIGLEC10 sialic acid binding Ig-like lectin 10
SPI1 Spi-1 proto-oncogene
TANK TRAF family member-associated NFKB activator
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNIP1 TNFAIP3 interacting protein 1
TRAF3IP2 TRAF3 interacting protein 2
TYROBP TYRO protein tyrosine kinase binding protein
WAS Wiskott-Aldrich syndrome
ZC3H12A zinc finger CCCH-type containing 12A
ZNF318 zinc finger protein 318