increased marginal zone b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL (Mammalian Phenotype Ontology, MP_0008181)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008181
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Genes

27 gene mutations causing the increased marginal zone b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
APOE apolipoprotein E
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
CD72 CD72 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CR2 complement component (3d/Epstein Barr virus) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DLK1 delta-like 1 homolog (Drosophila)
EPS15 epidermal growth factor receptor pathway substrate 15
FAS Fas cell surface death receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GAPT GRB2-binding adaptor protein, transmembrane
IGHM immunoglobulin heavy constant mu
IRF8 interferon regulatory factor 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PRKCD protein kinase C, delta
PTPRJ protein tyrosine phosphatase, receptor type, J
RGS1 regulator of G-protein signaling 1
SH3BP2 SH3-domain binding protein 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAF3IP2 TRAF3 interacting protein 2