increased mammary gland tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0010299)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010299
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Genes

35 gene mutations causing the increased mammary gland tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTB actin, beta
APC adenomatous polyposis coli
BECN1 beclin 1, autophagy related
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
DKC1 dyskeratosis congenita 1, dyskerin
ETV6 ets variant 6
FBXO4 F-box protein 4
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPX7 glutathione peroxidase 7
HELQ helicase, POLQ-like
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
LZTS1 leucine zipper, putative tumor suppressor 1
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MSH2 mutS homolog 2
NBN nibrin
NF2 neurofibromin 2 (merlin)
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PRDX1 peroxiredoxin 1
PTEN phosphatase and tensin homolog
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
S100A4 S100 calcium binding protein A4
SIRT2 sirtuin 2
STK3 serine/threonine kinase 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TRIM62 tripartite motif containing 62