increased liver weight Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description a greater than average weight of the bile-secreting exocrine gland (Mammalian Phenotype Ontology, MP_0002981)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002981
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Genes

82 gene mutations causing the increased liver weight phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ACOX1 acyl-CoA oxidase 1, palmitoyl
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALMS1 Alstrom syndrome protein 1
ANGPTL3 angiopoietin-like 3
ASIP agouti signaling protein
BCKDK branched chain ketoacid dehydrogenase kinase
BHMT betaine--homocysteine S-methyltransferase
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CAV1 caveolin 1, caveolae protein, 22kDa
CLCA2 chloride channel accessory 2
CUL3 cullin 3
CYBRD1 cytochrome b reductase 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DFNB31 deafness, autosomal recessive 31
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
FABP2 fatty acid binding protein 2, intestinal
FADS2 fatty acid desaturase 2
FECH ferrochelatase
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
G6PC glucose-6-phosphatase, catalytic subunit
GBA glucosidase, beta, acid
GNMT glycine N-methyltransferase
GPI glucose-6-phosphate isomerase
GPR12 G protein-coupled receptor 12
GSTZ1 glutathione S-transferase zeta 1
GTF2IRD1 GTF2I repeat domain containing 1
HNF1A HNF1 homeobox A
IFITM1 interferon induced transmembrane protein 1
IGF2 insulin-like growth factor 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
KIFAP3 kinesin-associated protein 3
KLF3 Kruppel-like factor 3 (basic)
KLF6 Kruppel-like factor 6
KMT2B lysine (K)-specific methyltransferase 2B
LDHA lactate dehydrogenase A
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LTA lymphotoxin alpha
MARVELD2 MARVEL domain containing 2
MAT1A methionine adenosyltransferase I, alpha
MC4R melanocortin 4 receptor
MLXIPL MLX interacting protein-like
NCOA6 nuclear receptor coactivator 6
NDFIP1 Nedd4 family interacting protein 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
OCA2 oculocutaneous albinism II
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
OTC ornithine carbamoyltransferase
PAPPA2 pappalysin 2
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PREP prolyl endopeptidase
RDH16 retinol dehydrogenase 16 (all-trans)
SC5D sterol-C5-desaturase
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOD2 superoxide dismutase 2, mitochondrial
SPI1 Spi-1 proto-oncogene
STEAP4 STEAP family member 4
STX2 syntaxin 2
TNF tumor necrosis factor
TXNIP thioredoxin interacting protein
XYLT2 xylosyltransferase II