increased leukemia incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002026
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Genes

33 gene mutations causing the increased leukemia incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALOX15 arachidonate 15-lipoxygenase
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
BLNK B-cell linker
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CREBBP CREB binding protein
CTSG cathepsin G
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ESR2 estrogen receptor 2 (ER beta)
ETV6 ets variant 6
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GPX7 glutathione peroxidase 7
HMGA1 high mobility group AT-hook 1
HR hair growth associated
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF8 interferon regulatory factor 8
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
MCM4 minichromosome maintenance complex component 4
NF1 neurofibromin 1
PTEN phosphatase and tensin homolog
RAD50 RAD50 homolog (S. cerevisiae)
SAMD9L sterile alpha motif domain containing 9-like
SIPA1 signal-induced proliferation-associated 1
SMAP1 small ArfGAP 1
SOAT1 sterol O-acyltransferase 1
SPI1 Spi-1 proto-oncogene
TET2 tet methylcytosine dioxygenase 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TP53 tumor protein p53
TUSC2 tumor suppressor candidate 2