increased intestinal adenoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0002404)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002404
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Genes

19 gene mutations causing the increased intestinal adenoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APC adenomatous polyposis coli
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
CDX2 caudal type homeobox 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCC DCC netrin 1 receptor
HELQ helicase, POLQ-like
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
MSH6 mutS homolog 6
NUAK2 NUAK family, SNF1-like kinase, 2
PAX6 paired box 6
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
SMAD4 SMAD family member 4
STK11 serine/threonine kinase 11
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated