increased integument system tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in the integument system in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010293)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010293
Similar Terms
Downloads & Tools

Genes

72 gene mutations causing the increased integument system tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTB actin, beta
APC adenomatous polyposis coli
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AURKB aurora kinase B
BECN1 beclin 1, autophagy related
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAV1 caveolin 1, caveolae protein, 22kDa
CD34 CD34 molecule
CDK11A cyclin-dependent kinase 11A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHUK conserved helix-loop-helix ubiquitous kinase
CYLD cylindromatosis (turban tumor syndrome)
DKC1 dyskeratosis congenita 1, dyskerin
EAF2 ELL associated factor 2
EGR1 early growth response 1
ERCC2 excision repair cross-complementation group 2
ERRFI1 ERBB receptor feedback inhibitor 1
ETV6 ets variant 6
FBXO4 F-box protein 4
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPX7 glutathione peroxidase 7
GRM1 glutamate receptor, metabotropic 1
GSTP1 glutathione S-transferase pi 1
HELQ helicase, POLQ-like
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT9 keratin 9, type I
LZTS1 leucine zipper, putative tumor suppressor 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
NBN nibrin
NF2 neurofibromin 2 (merlin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PAQR3 progestin and adipoQ receptor family member III
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLCD1 phospholipase C, delta 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLH polymerase (DNA directed), eta
PPARD peroxisome proliferator-activated receptor delta
PRDX1 peroxiredoxin 1
PRKCA protein kinase C, alpha
PRKCH protein kinase C, eta
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
S100A4 S100 calcium binding protein A4
SFN stratifin
SIRT2 sirtuin 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
STK3 serine/threonine kinase 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TRIM62 tripartite motif containing 62
XPA xeroderma pigmentosum, complementation group A