increased insulin sensitivity Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia (Mammalian Phenotype Ontology, MP_0002891)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002891
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Genes

132 gene mutations causing the increased insulin sensitivity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKAP5 A kinase (PRKA) anchor protein 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPTL2 angiopoietin-like 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRDC3 arrestin domain containing 3
ATF4 activating transcription factor 4
BBS12 Bardet-Biedl syndrome 12
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CADPS2 Ca++-dependent secretion activator 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL13 chemokine (C-C motif) ligand 13
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
CRBN cereblon
CREBBP CREB binding protein
CRHR2 corticotropin releasing hormone receptor 2
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R4 cytochrome b5 reductase 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DGAT1 diacylglycerol O-acyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
E2F1 E2F transcription factor 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR2 estrogen receptor 2 (ER beta)
FABP3 fatty acid binding protein 3, muscle and heart
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FFAR1 free fatty acid receptor 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
G0S2 G0/G1 switch 2
GCG glucagon
GCGR glucagon receptor
GHR growth hormone receptor
GNAS GNAS complex locus
GPR21 G protein-coupled receptor 21
GPR68 G protein-coupled receptor 68
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GSK3A glycogen synthase kinase 3 alpha
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGA1 high mobility group AT-hook 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSR insulin receptor
IP6K1 inositol hexakisphosphate kinase 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KL klotho
LCLAT1 lysocardiolipin acyltransferase 1
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LRP6 low density lipoprotein receptor-related protein 6
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD5 methyl-CpG binding domain protein 5
MGLL monoglyceride lipase
MSTN myostatin
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NLN neurolysin (metallopeptidase M3 family)
NOS2 nitric oxide synthase 2, inducible
OMA1 OMA1 zinc metallopeptidase
PASK PAS domain containing serine/threonine kinase
PBX1 pre-B-cell leukemia homeobox 1
PDE10A phosphodiesterase 10A
PHIP pleckstrin homology domain interacting protein
PHOX2A paired-like homeobox 2a
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G1B phospholipase A2, group IB (pancreas)
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RCAN2 regulator of calcineurin 2
RPS6 ribosomal protein S6
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERTAD2 SERTA domain containing 2
SGMS1 sphingomyelin synthase 1
SGMS2 sphingomyelin synthase 2
SIRT6 sirtuin 6
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SOCS3 suppressor of cytokine signaling 3
SOCS7 suppressor of cytokine signaling 7
SORBS1 sorbin and SH3 domain containing 1
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SSTR5 somatostatin receptor 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRA6 stimulated by retinoic acid 6
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2
TMEM27 transmembrane protein 27
TXNIP thioredoxin interacting protein
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VIPR1 vasoactive intestinal peptide receptor 1
VIPR2 vasoactive intestinal peptide receptor 2
ZBTB20 zinc finger and BTB domain containing 20