increased incidence of tumors by chemical induction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens (Mammalian Phenotype Ontology, MP_0004499)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004499
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Genes

86 gene mutations causing the increased incidence of tumors by chemical induction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
APC adenomatous polyposis coli
ATG4C autophagy related 4C, cysteine peptidase
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CASC1 cancer susceptibility candidate 1
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CD226 CD226 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CUL9 cullin 9
CYGB cytoglobin
CYLD cylindromatosis (turban tumor syndrome)
EGR1 early growth response 1
EPHA2 EPH receptor A2
ERCC2 excision repair cross-complementation group 2
ERRFI1 ERBB receptor feedback inhibitor 1
FHIT fragile histidine triad
FLCN folliculin
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
FPR2 formyl peptide receptor 2
GAST gastrin
HINT1 histidine triad nucleotide binding protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IL12A interleukin 12A
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IP6K2 inositol hexakisphosphate kinase 2
IRF1 interferon regulatory factor 1
KLF10 Kruppel-like factor 10
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MSH2 mutS homolog 2
MXI1 MAX interactor 1, dimerization protein
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NFE2L2 nuclear factor, erythroid 2-like 2
NIT1 nitrilase 1
NLRP12 NLR family, pyrin domain containing 12
NLRP6 NLR family, pyrin domain containing 6
PAQR3 progestin and adipoQ receptor family member III
PLCL1 phospholipase C-like 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKCH protein kinase C, eta
PTPRT protein tyrosine phosphatase, receptor type, T
RAE1 ribonucleic acid export 1
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGPD1 RANBP2-like and GRIP domain containing 1
RHOB ras homolog family member B
SF1 splicing factor 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK11 serine/threonine kinase 11
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP73 tumor protein p73
TREX2 three prime repair exonuclease 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC1 tuberous sclerosis 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UIMC1 ubiquitin interaction motif containing 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A