increased igm level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormally increased level of immunoglobulin M in blood. (Human Phenotype Ontology, HP_0003496)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002494
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Genes

93 gene mutations causing the increased igm level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
APOE apolipoprotein E
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC3 baculoviral IAP repeat containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
CCDC171 coiled-coil domain containing 171
CCR6 chemokine (C-C motif) receptor 6
CD22 CD22 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CD72 CD72 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CIITA class II, major histocompatibility complex, transactivator
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FLT3LG fms-related tyrosine kinase 3 ligand
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB2 GA binding protein transcription factor, beta subunit 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAPT GRB2-binding adaptor protein, transmembrane
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HRH1 histamine receptor H1
IGHM immunoglobulin heavy constant mu
IL13 interleukin 13
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK1 Janus kinase 1
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAVS mitochondrial antiviral signaling protein
MIR150 microRNA 150
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NHEJ1 nonhomologous end-joining factor 1
NIPAL3 NIPA-like domain containing 3
NPY1R neuropeptide Y receptor Y1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKN1 protein kinase N1
PLCL2 phospholipase C-like 2
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS13 regulator of G-protein signaling 13
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
SIGLEC10 sialic acid binding Ig-like lectin 10
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TROVE2 TROVE domain family, member 2
UNG uracil-DNA glycosylase
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF318 zinc finger protein 318