increased igg level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormally increased level of immunoglobulin G in blood. (Human Phenotype Ontology, HP_0003237)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002493
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Genes

162 gene mutations causing the increased igg level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY9 adenylate cyclase 9
AMPD3 adenosine monophosphate deaminase 3
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
AVPR1A arginine vasopressin receptor 1A
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
C1QTNF3 C1q and tumor necrosis factor related protein 3
CABIN1 calcineurin binding protein 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD1D CD1d molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD81 CD81 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CH25H cholesterol 25-hydroxylase
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLK1 CDC-like kinase 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FCRLA Fc receptor-like A
FCRLB Fc receptor-like B
FLG filaggrin
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB2 GA binding protein transcription factor, beta subunit 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAP43 growth associated protein 43
GAPT GRB2-binding adaptor protein, transmembrane
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR132 G protein-coupled receptor 132
HLA-DOA major histocompatibility complex, class II, DO alpha
HR hair growth associated
HRH1 histamine receptor H1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL17F interleukin 17F
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK1 Janus kinase 1
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS3 lectin, galactoside-binding, soluble, 3
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAVS mitochondrial antiviral signaling protein
MIR150 microRNA 150
MTA3 metastasis associated 1 family, member 3
MYD88 myeloid differentiation primary response 88
MYSM1 Myb-like, SWIRM and MPN domains 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NIPAL3 NIPA-like domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIGR polymeric immunoglobulin receptor
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCD protein kinase C, delta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RETNLB resistin like beta
RGS13 regulator of G-protein signaling 13
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARF1 scavenger receptor class F, member 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SH2B2 SH2B adaptor protein 2
SH2D1A SH2 domain containing 1A
SIAE sialic acid acetylesterase
SNX5 sorting nexin 5
SPTA1 spectrin, alpha, erythrocytic 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TANK TRAF family member-associated NFKB activator
TBC1D10C TBC1 domain family, member 10C
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLR8 toll-like receptor 8
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TROVE2 TROVE domain family, member 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
UXS1 UDP-glucuronate decarboxylase 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H12A zinc finger CCCH-type containing 12A