increased ige level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormally increased level of immunoglobulin E in blood. (Human Phenotype Ontology, HP_0003212)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002497
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Genes

60 gene mutations causing the increased ige level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BHLHE40 basic helix-loop-helix family, member e40
BTK Bruton agammaglobulinemia tyrosine kinase
CABIN1 calcineurin binding protein 1
CARD11 caspase recruitment domain family, member 11
CCR4 chemokine (C-C motif) receptor 4
CCR7 chemokine (C-C motif) receptor 7
CTSE cathepsin E
CXCR2 chemokine (C-X-C motif) receptor 2
DSG3 desmoglein 3
DSG4 desmoglein 4
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLG filaggrin
FOXP3 forkhead box P3
IFITM1 interferon induced transmembrane protein 1
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL13RA2 interleukin 13 receptor, alpha 2
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL25 interleukin 25
IL2RB interleukin 2 receptor, beta
IL31RA interleukin 31 receptor A
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LPAR2 lysophosphatidic acid receptor 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NIPAL3 NIPA-like domain containing 3
PIGR polymeric immunoglobulin receptor
PPIA peptidylprolyl isomerase A (cyclophilin A)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RORA RAR-related orphan receptor A
RUNX3 runt-related transcription factor 3
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SIAE sialic acid acetylesterase
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TMEM79 transmembrane protein 79
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TRAF3IP2 TRAF3 interacting protein 2
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa