increased histiocytic sarcoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of malignant tumors derived from histiocytes in a given population in a given time period (Mammalian Phenotype Ontology, MP_0009321)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009321
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Genes

20 gene mutations causing the increased histiocytic sarcoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BECN1 beclin 1, autophagy related
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CREBBP CREB binding protein
DCLRE1A DNA cross-link repair 1A
E2F1 E2F transcription factor 1
FASLG Fas ligand (TNF superfamily, member 6)
FBXO4 F-box protein 4
FLT3 fms-related tyrosine kinase 3
ING2 inhibitor of growth family, member 2
MET MET proto-oncogene, receptor tyrosine kinase
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
POLE polymerase (DNA directed), epsilon, catalytic subunit
PRDX1 peroxiredoxin 1
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
STAG1 stromal antigen 1
STK4 serine/threonine kinase 4
TP53 tumor protein p53
TP63 tumor protein p63