increased hemolymphoid system tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010296)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010296
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Genes

161 gene mutations causing the increased hemolymphoid system tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
ALOX15 arachidonate 15-lipoxygenase
ANXA7 annexin A7
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BECN1 beclin 1, autophagy related
BIN3 bridging integrator 3
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BMF Bcl2 modifying factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDC20 cell division cycle 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD2 chromodomain helicase DNA binding protein 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CREBBP CREB binding protein
CTSG cathepsin G
CUL9 cullin 9
DCLRE1A DNA cross-link repair 1A
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR2 estrogen receptor 2 (ER beta)
ETV6 ets variant 6
EXO1 exonuclease 1
FASLG Fas ligand (TNF superfamily, member 6)
FBXO4 F-box protein 4
FEN1 flap structure-specific endonuclease 1
FHIT fragile histidine triad
FLCN folliculin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3 fms-related tyrosine kinase 3
GPX7 glutathione peroxidase 7
H2AFX H2A histone family, member X
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HIC1 hypermethylated in cancer 1
HMGA1 high mobility group AT-hook 1
HR hair growth associated
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
JAK2 Janus kinase 2
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LZTS1 leucine zipper, putative tumor suppressor 1
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTF1 metal-regulatory transcription factor 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH14 myosin, heavy chain 14, non-muscle
MZF1 myeloid zinc finger 1
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NME1 NME/NM23 nucleoside diphosphate kinase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER2 period circadian clock 2
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLK1 polo-like kinase 1
PML promyelocytic leukemia
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLG polymerase (DNA directed), gamma
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RAD50 RAD50 homolog (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RBBP8 retinoblastoma binding protein 8
RC3H1 ring finger and CCCH-type domains 1
RECQL4 RecQ protein-like 4
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA1 replication protein A1, 70kDa
RUNX1 runt-related transcription factor 1
S100A4 S100 calcium binding protein A4
SAMD9L sterile alpha motif domain containing 9-like
SAV1 salvador family WW domain containing protein 1
SIPA1 signal-induced proliferation-associated 1
SIRT2 sirtuin 2
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMAP1 small ArfGAP 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOAT1 sterol O-acyltransferase 1
SOD2 superoxide dismutase 2, mitochondrial
SPI1 Spi-1 proto-oncogene
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SSBP2 single-stranded DNA binding protein 2
STAG1 stromal antigen 1
STK4 serine/threonine kinase 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TCF3 transcription factor 3
TERC telomerase RNA component
TET2 tet methylcytosine dioxygenase 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMPRSS11D transmembrane protease, serine 11D
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM62 tripartite motif containing 62
TUSC2 tumor suppressor candidate 2
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
USP44 ubiquitin specific peptidase 44
WWOX WW domain containing oxidoreductase
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1