increased hematopoietic stem cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages (Mammalian Phenotype Ontology, MP_0004809)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004809
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Genes

26 gene mutations causing the increased hematopoietic stem cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4A AT rich interactive domain 4A (RBP1-like)
ASXL1 additional sex combs like transcriptional regulator 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
ELF4 E74-like factor 4 (ets domain transcription factor)
GFI1 growth factor independent 1 transcription repressor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HOXA9 homeobox A9
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KMT2E lysine (K)-specific methyltransferase 2E
MAN2A1 mannosidase, alpha, class 2A, member 1
MATK megakaryocyte-associated tyrosine kinase
MYB v-myb avian myeloblastosis viral oncogene homolog
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PER2 period circadian clock 2
PFKM phosphofructokinase, muscle
RUNX1 runt-related transcription factor 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SIPA1 signal-induced proliferation-associated 1
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
TAL1 T-cell acute lymphocytic leukemia 1
TET2 tet methylcytosine dioxygenase 2