increased heart weight Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than average weight of the heart compared to controls (Mammalian Phenotype Ontology, MP_0002833)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002833
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Genes

127 gene mutations causing the increased heart weight phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ADGRF5 adhesion G protein-coupled receptor F5
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AMER1 APC membrane recruitment protein 1
ANK1 ankyrin 1, erythrocytic
ANKRD26 ankyrin repeat domain 26
APOE apolipoprotein E
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASQ2 calsequestrin 2 (cardiac muscle)
CD28 CD28 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CKM creatine kinase, muscle
CNOT3 CCR4-NOT transcription complex, subunit 3
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTNNA3 catenin (cadherin-associated protein), alpha 3
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DFNB31 deafness, autosomal recessive 31
DRD5 dopamine receptor D5
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
ESR2 estrogen receptor 2 (ER beta)
FABP3 fatty acid binding protein 3, muscle and heart
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSTL3 follistatin-like 3 (secreted glycoprotein)
FXYD1 FXYD domain containing ion transport regulator 1
GATA5 GATA binding protein 5
GLA galactosidase, alpha
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GRB14 growth factor receptor-bound protein 14
GSTO2 glutathione S-transferase omega 2
GUCY2C guanylate cyclase 2C
GYS1 glycogen synthase 1 (muscle)
HBEGF heparin-binding EGF-like growth factor
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IDUA iduronidase, alpha-L-
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLF3 Kruppel-like factor 3 (basic)
KLK3 kallikrein-related peptidase 3
LAMP2 lysosomal-associated membrane protein 2
LDB3 LIM domain binding 3
LDHA lactate dehydrogenase A
LEP leptin
LTA lymphotoxin alpha
LTBP4 latent transforming growth factor beta binding protein 4
MARVELD2 MARVEL domain containing 2
MSTN myostatin
MTUS1 microtubule associated tumor suppressor 1
MYBPC3 myosin binding protein C, cardiac
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK3 myosin light chain kinase 3
MYO6 myosin VI
NCOR1 nuclear receptor corepressor 1
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK6 NIMA-related kinase 6
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAPPA2 pappalysin 2
PDLIM5 PDZ and LIM domain 5
PFKM phosphofructokinase, muscle
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLN phospholamban
PNPLA2 patatin-like phospholipase domain containing 2
POLG polymerase (DNA directed), gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RCAN1 regulator of calcineurin 1
RRAD Ras-related associated with diabetes
RYR2 ryanodine receptor 2 (cardiac)
SFRP1 secreted frizzled-related protein 1
SIRT2 sirtuin 2
SIRT7 sirtuin 7
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMTN smoothelin
SOD2 superoxide dismutase 2, mitochondrial
SPEG SPEG complex locus
SPNS1 spinster homolog 1 (Drosophila)
TBC1D2B TBC1 domain family, member 2B
TBC1D4 TBC1 domain family, member 4
THBS4 thrombospondin 4
TIMP4 TIMP metallopeptidase inhibitor 4
TNF tumor necrosis factor
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRIM55 tripartite motif containing 55
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TTN titin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFB vascular endothelial growth factor B
XIRP2 xin actin binding repeat containing 2
XYLB xylulokinase homolog (H. influenzae)
ZFPM1 zinc finger protein, FOG family member 1
ZMPSTE24 zinc metallopeptidase STE24