increased granulocyte number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils (Mammalian Phenotype Ontology, MP_0000322)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000322
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Genes

200 gene mutations causing the increased granulocyte number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRE5 adhesion G protein-coupled receptor E5
AGR2 anterior gradient 2
ALOX15 arachidonate 15-lipoxygenase
AMPD3 adenosine monophosphate deaminase 3
ANK1 ankyrin 1, erythrocytic
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP7B ATPase, Cu++ transporting, beta polypeptide
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
C4A complement component 4A (Rodgers blood group)
CAMP cathelicidin antimicrobial peptide
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CD300A CD300a molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CISH cytokine inducible SH2-containing protein
CLCA1 chloride channel accessory 1
CMKLR1 chemerin chemokine-like receptor 1
CREBBP CREB binding protein
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSE cathepsin E
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCC DCC netrin 1 receptor
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIAPH1 diaphanous-related formin 1
DIDO1 death inducer-obliterator 1
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
ELMOD1 ELMO/CED-12 domain containing 1
ESR2 estrogen receptor 2 (ER beta)
FAM104A family with sequence similarity 104, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FES FES proto-oncogene, tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD9 frizzled class receptor 9
G6PC3 glucose 6 phosphatase, catalytic, 3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPRC5C G protein-coupled receptor, class C, group 5, member C
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HCK HCK proto-oncogene, Src family tyrosine kinase
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL1RL1 interleukin 1 receptor-like 1
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL36RN interleukin 36 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK3 interleukin-1 receptor-associated kinase 3
IRF8 interferon regulatory factor 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JAM3 junctional adhesion molecule 3
KDM5A lysine (K)-specific demethylase 5A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MEFV Mediterranean fever
MIR223 microRNA 223
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MXD1 MAX dimerization protein 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYSM1 Myb-like, SWIRM and MPN domains 1
NCKAP1L NCK-associated protein 1-like
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OED Oregon eye disease
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PILRA paired immunoglobin-like type 2 receptor alpha
PITX3 paired-like homeodomain 3
PLAC8 placenta-specific 8
PLCD1 phospholipase C, delta 1
POMT1 protein-O-mannosyltransferase 1
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS50 protease, serine, 50
PTCH2 patched 2
PTGDR2 prostaglandin D2 receptor 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RBP1 retinol binding protein 1, cellular
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIC1 RAB6A GEF complex partner 1
RUNX2 runt-related transcription factor 2
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETMAR SET domain and mariner transposase fusion gene
SFTPD surfactant protein D
SGPL1 sphingosine-1-phosphate lyase 1
SH2B3 SH2B adaptor protein 3
SHARPIN SHANK-associated RH domain interactor
SIGLEC8 sialic acid binding Ig-like lectin 8
SIPA1 signal-induced proliferation-associated 1
SIRT7 sirtuin 7
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD3 SMAD family member 3
SMAP1 small ArfGAP 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SPI1 Spi-1 proto-oncogene
SPINK5 serine peptidase inhibitor, Kazal type 5
SPNS2 spinster homolog 2 (Drosophila)
SPRED1 sprouty-related, EVH1 domain containing 1
SPTA1 spectrin, alpha, erythrocytic 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYK spleen tyrosine kinase
T T, brachyury homolog (mouse)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TET2 tet methylcytosine dioxygenase 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLX1 T-cell leukemia homeobox 1
TMC6 transmembrane channel-like 6
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNIP1 TNFAIP3 interacting protein 1
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TRAF2 TNF receptor-associated factor 2
TRIB1 tribbles pseudokinase 1
TSTA3 tissue specific transplantation antigen P35B
TWSG1 twisted gastrulation BMP signaling modulator 1
UNC13D unc-13 homolog D (C. elegans)
USP21 ubiquitin specific peptidase 21
USP25 ubiquitin specific peptidase 25
VTCN1 V-set domain containing T cell activation inhibitor 1
WAS Wiskott-Aldrich syndrome
WDR1 WD repeat domain 1
WDR37 WD repeat domain 37
ZBTB46 zinc finger and BTB domain containing 46
ZDHHC13 zinc finger, DHHC-type containing 13
ZFP36 ZFP36 ring finger protein
ZFPM1 zinc finger protein, FOG family member 1