increased gland tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in a gland in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010288)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010288
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Genes

117 gene mutations causing the increased gland tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACPP acid phosphatase, prostate
ACTB actin, beta
AIP aryl hydrocarbon receptor interacting protein
AMHR2 anti-Mullerian hormone receptor, type II
APC adenomatous polyposis coli
AR androgen receptor
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
BECN1 beclin 1, autophagy related
BHLHA15 basic helix-loop-helix family, member a15
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHD2 chromodomain helicase DNA binding protein 2
CUL9 cullin 9
DCLRE1A DNA cross-link repair 1A
DKC1 dyskeratosis congenita 1, dyskerin
DND1 DND microRNA-mediated repression inhibitor 1
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ETV6 ets variant 6
FBXO4 F-box protein 4
FOXO3 forkhead box O3
FSHR follicle stimulating hormone receptor
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GON4L gon-4-like (C. elegans)
GPX7 glutathione peroxidase 7
H2AFX H2A histone family, member X
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HELQ helicase, POLQ-like
HIC1 hypermethylated in cancer 1
HMGN1 high mobility group nucleosome binding domain 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INHA inhibin, alpha
KITLG KIT ligand
KRAS Kirsten rat sarcoma viral oncogene homolog
LATS1 large tumor suppressor kinase 1
LIG4 ligase IV, DNA, ATP-dependent
LZTS1 leucine zipper, putative tumor suppressor 1
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSMB microseminoprotein, beta-
MTF1 metal-regulatory transcription factor 1
NBN nibrin
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NKX3-1 NK3 homeobox 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PER2 period circadian clock 2
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRL prolactin
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
RAD50 RAD50 homolog (S. cerevisiae)
RB1 retinoblastoma 1
RC3H1 ring finger and CCCH-type domains 1
RET ret proto-oncogene
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
S100A4 S100 calcium binding protein A4
SAV1 salvador family WW domain containing protein 1
SF1 splicing factor 1
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SMAD4 SMAD family member 4
SPI1 Spi-1 proto-oncogene
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STK3 serine/threonine kinase 3
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
THRB thyroid hormone receptor, beta
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TRIM62 tripartite motif containing 62
UIMC1 ubiquitin interaction motif containing 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1
ZFHX3 zinc finger homeobox 3