increased fibrosarcoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0010363)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010363
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Genes

12 gene mutations causing the increased fibrosarcoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN2A cyclin-dependent kinase inhibitor 2A
DKC1 dyskeratosis congenita 1, dyskerin
KRAS Kirsten rat sarcoma viral oncogene homolog
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP8 matrix metallopeptidase 8
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
PRDX1 peroxiredoxin 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
S100A4 S100 calcium binding protein A4
TP53 tumor protein p53