increased fatty acid level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description elevated concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated (Mammalian Phenotype Ontology, MP_0005281)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005281
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Genes

88 gene mutations causing the increased fatty acid level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ACADL acyl-CoA dehydrogenase, long chain
ACOT11 acyl-CoA thioesterase 11
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
AMACR alpha-methylacyl-CoA racemase
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
BCO1 beta-carotene oxygenase 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
CCDC120 coiled-coil domain containing 120
CCDC80 coiled-coil domain containing 80
CD36 CD36 molecule (thrombospondin receptor)
CPT1A carnitine palmitoyltransferase 1A (liver)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CYB561 cytochrome b561
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
ECI1 enoyl-CoA delta isomerase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FGF21 fibroblast growth factor 21
FOXA2 forkhead box A2
G0S2 G0/G1 switch 2
GCK glucokinase (hexokinase 4)
GNAS GNAS complex locus
HADH hydroxyacyl-CoA dehydrogenase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HRH1 histamine receptor H1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IL10 interleukin 10
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KMT2B lysine (K)-specific methyltransferase 2B
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LONRF3 LON peptidase N-terminal domain and ring finger 3
LPIN1 lipin 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MC4R melanocortin 4 receptor
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MTRF1L mitochondrial translational release factor 1-like
MYO7A myosin VIIA
NCOR1 nuclear receptor corepressor 1
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NEU4 sialidase 4
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
OSMR oncostatin M receptor
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEX1 peroxisomal biogenesis factor 1
PEX11A peroxisomal biogenesis factor 11 alpha
PEX7 peroxisomal biogenesis factor 7
PLIN5 perilipin 5
PLSCR3 phospholipid scramblase 3
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCI protein kinase C, iota
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PTRF polymerase I and transcript release factor
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SGMS2 sphingomyelin synthase 2
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THEM5 thioesterase superfamily member 5
TLR2 toll-like receptor 2
TXNIP thioredoxin interacting protein
TYK2 tyrosine kinase 2
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
ZEB1 zinc finger E-box binding homeobox 1