increased double-positive t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8 (Mammalian Phenotype Ontology, MP_0005091)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005091
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Genes

27 gene mutations causing the increased double-positive t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATM ATM serine/threonine kinase
CADM1 cell adhesion molecule 1
CCR6 chemokine (C-C motif) receptor 6
CD4 CD4 molecule
CD7 CD7 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CIITA class II, major histocompatibility complex, transactivator
CTSE cathepsin E
CYLD cylindromatosis (turban tumor syndrome)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOXN1 forkhead box N1
IL7R interleukin 7 receptor
IRF1 interferon regulatory factor 1
ITPKB inositol-trisphosphate 3-kinase B
KLF13 Kruppel-like factor 13
MMP19 matrix metallopeptidase 19
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RUNX1 runt-related transcription factor 1
SIT1 signaling threshold regulating transmembrane adaptor 1
THEMIS thymocyte selection associated
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa