increased double-negative t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 (Mammalian Phenotype Ontology, MP_0005090)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005090
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Genes

62 gene mutations causing the increased double-negative t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
BCL10 B-cell CLL/lymphoma 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
CCNB2 cyclin B2
CCND3 cyclin D3
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD5 CD5 molecule
CDK6 cyclin-dependent kinase 6
COL10A1 collagen, type X, alpha 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DCK deoxycytidine kinase
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F4 E2F transcription factor 4, p107/p130-binding
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FOXN1 forkhead box N1
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HELLS helicase, lymphoid-specific
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IL2 interleukin 2
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAML1 mastermind-like 1 (Drosophila)
MAPK14 mitogen-activated protein kinase 14
NCKAP1L NCK-associated protein 1-like
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOD2 nucleotide-binding oligomerization domain containing 2
PAX1 paired box 1
PKNOX1 PBX/knotted 1 homeobox 1
PNP purine nucleoside phosphorylase
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RHOH ras homolog family member H
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
SPI1 Spi-1 proto-oncogene
SYK spleen tyrosine kinase
TBATA thymus, brain and testes associated
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF4 transcription factor 4
TET2 tet methylcytosine dioxygenase 2
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
VAV1 vav 1 guanine nucleotide exchange factor
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZBTB7B zinc finger and BTB domain containing 7B