increased circulating tumor necrosis factor level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008553)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008553
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Genes

55 gene mutations causing the increased circulating tumor necrosis factor level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BRD2 bromodomain containing 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CD44 CD44 molecule (Indian blood group)
DUSP1 dual specificity phosphatase 1
FASLG Fas ligand (TNF superfamily, member 6)
FFAR2 free fatty acid receptor 2
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
HCK HCK proto-oncogene, Src family tyrosine kinase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL18 interleukin 18
IL27RA interleukin 27 receptor, alpha
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LGMN legumain
LIF leukemia inhibitory factor
MAVS mitochondrial antiviral signaling protein
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
PCSK1 proprotein convertase subtilisin/kexin type 1
PRF1 perforin 1 (pore forming protein)
RAB27A RAB27A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RC3H1 ring finger and CCCH-type domains 1
SH3BP2 SH3-domain binding protein 2
SIRT3 sirtuin 3
SLAMF6 SLAM family member 6
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX11 syntaxin 11
TBC1D23 TBC1 domain family, member 23
TBK1 TANK-binding kinase 1
THBD thrombomodulin
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
UNC93B1 unc-93 homolog B1 (C. elegans)
ZC3H12A zinc finger CCCH-type containing 12A