increased circulating interleukin-6 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts (Mammalian Phenotype Ontology, MP_0008596)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008596
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Genes

60 gene mutations causing the increased circulating interleukin-6 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAG4 BCL2-associated athanogene 4
CAV1 caveolin 1, caveolae protein, 22kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CRH corticotropin releasing hormone
CTSC cathepsin C
CXCR2 chemokine (C-X-C motif) receptor 2
DUSP1 dual specificity phosphatase 1
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL1RN interleukin 1 receptor antagonist
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIF leukemia inhibitory factor
LRRC4C leucine rich repeat containing 4C
LYN LYN proto-oncogene, Src family tyrosine kinase
MAVS mitochondrial antiviral signaling protein
MC4R melanocortin 4 receptor
MEFV Mediterranean fever
MEP1A meprin A, alpha (PABA peptide hydrolase)
MIR122 microRNA 122
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
PCSK1 proprotein convertase subtilisin/kexin type 1
POMC proopiomelanocortin
PRF1 perforin 1 (pore forming protein)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB27A RAB27A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RHBDD3 rhomboid domain containing 3
SCARB1 scavenger receptor class B, member 1
SIRT3 sirtuin 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STX11 syntaxin 11
TBC1D23 TBC1 domain family, member 23
TBK1 TANK-binding kinase 1
THBD thrombomodulin
TLR4 toll-like receptor 4
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TP53 tumor protein p53
TRAFD1 TRAF-type zinc finger domain containing 1
USP18 ubiquitin specific peptidase 18