increased circulating hdl cholesterol level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion (Mammalian Phenotype Ontology, MP_0001556)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001556
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Genes

57 gene mutations causing the increased circulating hdl cholesterol level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADORA2B adenosine A2b receptor
ALMS1 Alstrom syndrome protein 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APOE apolipoprotein E
APOF apolipoprotein F
ARSK arylsulfatase family, member K
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BAG3 BCL2-associated athanogene 3
BBS4 Bardet-Biedl syndrome 4
BBS5 Bardet-Biedl syndrome 5
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPE carboxypeptidase E
CSPG4 chondroitin sulfate proteoglycan 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DFNB31 deafness, autosomal recessive 31
DIXDC1 DIX domain containing 1
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
ESR1 estrogen receptor 1
FABP3 fatty acid binding protein 3, muscle and heart
FFAR4 free fatty acid receptor 4
FGF10 fibroblast growth factor 10
FTO fat mass and obesity associated
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPR12 G protein-coupled receptor 12
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IRS2 insulin receptor substrate 2
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPC lipase, hepatic
LIPG lipase, endothelial
LPIN1 lipin 1
LPL lipoprotein lipase
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MRAP2 melanocortin 2 receptor accessory protein 2
NR1D1 nuclear receptor subfamily 1, group D, member 1
NRCAM neuronal cell adhesion molecule
PRLHR prolactin releasing hormone receptor
REG3G regenerating islet-derived 3 gamma
RGS4 regulator of G-protein signaling 4
SCARB1 scavenger receptor class B, member 1
SCP2 sterol carrier protein 2
SERF1A small EDRK-rich factor 1A (telomeric)
SIRT2 sirtuin 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOAT1 sterol O-acyltransferase 1
SOAT2 sterol O-acyltransferase 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSTR1 somatostatin receptor 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
UTS2 urotensin 2