increased cellular sensitivity to gamma-irradiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased incidence of cell death following exposure to gamma-irradiation (Mammalian Phenotype Ontology, MP_0002007)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002007
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Genes

47 gene mutations causing the increased cellular sensitivity to gamma-irradiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BRCA1 breast cancer 1, early onset
CCNG1 cyclin G1
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COPS6 COP9 signalosome subunit 6
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CREBBP CREB binding protein
DCLRE1C DNA cross-link repair 1C
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELAVL1 ELAV like RNA binding protein 1
ERCC3 excision repair cross-complementation group 3
FEN1 flap structure-specific endonuclease 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGN1 high mobility group nucleosome binding domain 1
LIG4 ligase IV, DNA, ATP-dependent
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MXD3 MAX dimerization protein 3
NBN nibrin
NHEJ1 nonhomologous end-joining factor 1
NINJ1 ninjurin 1
PARP14 poly (ADP-ribose) polymerase family, member 14
PARP2 poly (ADP-ribose) polymerase 2
PNP purine nucleoside phosphorylase
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAD9B RAD9 homolog B (S. pombe)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SIRT1 sirtuin 1
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIGAR TP53 induced glycolysis regulatory phosphatase
TP73 tumor protein p73
UIMC1 ubiquitin interaction motif containing 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6