increased cellular sensitivity to alkylating agents Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater incidence of cell death following exposure to agents that cause DNA damage (Mammalian Phenotype Ontology, MP_0008402)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008402
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Genes

10 gene mutations causing the increased cellular sensitivity to alkylating agents phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATMIN ATM interactor
ATR ATR serine/threonine kinase
CHD2 chromodomain helicase DNA binding protein 2
FANCC Fanconi anemia, complementation group C
MTF1 metal-regulatory transcription factor 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
SIRT6 sirtuin 6
SMC1A structural maintenance of chromosomes 1A
TIGAR TP53 induced glycolysis regulatory phosphatase
TP53BP1 tumor protein p53 binding protein 1