increased cd8-positive, alpha-beta t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions (Mammalian Phenotype Ontology, MP_0008078)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008078
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Genes

88 gene mutations causing the increased cd8-positive, alpha-beta t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRM1 adhesion regulating molecule 1
AKAP9 A kinase (PRKA) anchor protein 9
ARL4D ADP-ribosylation factor-like 4D
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BBC3 BCL2 binding component 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BMF Bcl2 modifying factor
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD19 CD19 molecule
CD274 CD274 molecule
CD4 CD4 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPJ centromere protein J
CHD7 chromodomain helicase DNA binding protein 7
CIITA class II, major histocompatibility complex, transactivator
CLEC4G C-type lectin domain family 4, member G
CRTAM cytotoxic and regulatory T cell molecule
CTSV cathepsin V
DCK deoxycytidine kinase
DLL1 delta-like 1 (Drosophila)
E2F1 E2F transcription factor 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM83G family with sequence similarity 83, member G
FBXO7 F-box protein 7
FOXP2 forkhead box P2
FOXP3 forkhead box P3
GPR15 G protein-coupled receptor 15
HAVCR1 hepatitis A virus cellular receptor 1
HELLS helicase, lymphoid-specific
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
HP1BP3 heterochromatin protein 1, binding protein 3
IFNG interferon, gamma
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITK IL2-inducible T-cell kinase
JAK3 Janus kinase 3
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
MPZL2 myelin protein zero-like 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCOA3 nuclear receptor coactivator 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPY1R neuropeptide Y receptor Y1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PITX3 paired-like homeodomain 3
PPP5C protein phosphatase 5, catalytic subunit
PRKCH protein kinase C, eta
PRMT3 protein arginine methyltransferase 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGS3 regulator of G-protein signaling 3
RRAS related RAS viral (r-ras) oncogene homolog
S1PR1 sphingosine-1-phosphate receptor 1
SETD1A SET domain containing 1A
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
SYK spleen tyrosine kinase
TCF12 transcription factor 12
TMEM127 transmembrane protein 127
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOM1L2 target of myb1-like 2 (chicken)
TRIB2 tribbles pseudokinase 2
UNC13D unc-13 homolog D (C. elegans)
ZBTB7B zinc finger and BTB domain containing 7B