increased cd4-positive, alpha beta t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production (Mammalian Phenotype Ontology, MP_0008074)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008074
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Genes

123 gene mutations causing the increased cd4-positive, alpha beta t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR4 atypical chemokine receptor 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRM1 adhesion regulating molecule 1
AKAP9 A kinase (PRKA) anchor protein 9
ANPEP alanyl (membrane) aminopeptidase
APOE apolipoprotein E
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
C17ORF62 chromosome 17 open reading frame 62
CARD11 caspase recruitment domain family, member 11
CBFB core-binding factor, beta subunit
CCL13 chemokine (C-C motif) ligand 13
CCR7 chemokine (C-C motif) receptor 7
CD4 CD4 molecule
CD40LG CD40 ligand
CD48 CD48 molecule
CD8A CD8a molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CHD2 chromodomain helicase DNA binding protein 2
CIITA class II, major histocompatibility complex, transactivator
CLEC4G C-type lectin domain family 4, member G
COL10A1 collagen, type X, alpha 1
CRTAM cytotoxic and regulatory T cell molecule
CXCR2 chemokine (C-X-C motif) receptor 2
DCK deoxycytidine kinase
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FBXO7 F-box protein 7
FOXP2 forkhead box P2
FOXP3 forkhead box P3
GRAP GRB2-related adaptor protein
HAVCR1 hepatitis A virus cellular receptor 1
HLA-A major histocompatibility complex, class I, A
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL10 interleukin 10
IL13RA1 interleukin 13 receptor, alpha 1
IL15RA interleukin 15 receptor, alpha
IL17RA interleukin 17 receptor A
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
IL9R interleukin 9 receptor
IRF1 interferon regulatory factor 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK3 Janus kinase 3
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LGALS9B lectin, galactoside-binding, soluble, 9B
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MIR155 microRNA 155
MMP9 matrix metallopeptidase 9
MPG N-methylpurine-DNA glycosylase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYSM1 Myb-like, SWIRM and MPN domains 1
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NPY1R neuropeptide Y receptor Y1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PITX3 paired-like homeodomain 3
PLA2G2D phospholipase A2, group IID
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP5C protein phosphatase 5, catalytic subunit
PRKCH protein kinase C, eta
PRMT3 protein arginine methyltransferase 3
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RC3H1 ring finger and CCCH-type domains 1
REG3G regenerating islet-derived 3 gamma
RGS3 regulator of G-protein signaling 3
RRAS related RAS viral (r-ras) oncogene homolog
RUNX1 runt-related transcription factor 1
S1PR1 sphingosine-1-phosphate receptor 1
SCARF1 scavenger receptor class F, member 1
SETD1A SET domain containing 1A
SETDB1 SET domain, bifurcated 1
SGPL1 sphingosine-1-phosphate lyase 1
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
STK17B serine/threonine kinase 17b
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1
TMEM127 transmembrane protein 127
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
UNC93B1 unc-93 homolog B1 (C. elegans)
USP42 ubiquitin specific peptidase 42
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
ZC3H12D zinc finger CCCH-type containing 12D
ZNF175 zinc finger protein 175