increased cardiovascular system tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in the cardiovascular system in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010291)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010291
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Genes

35 gene mutations causing the increased cardiovascular system tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTB actin, beta
ATAD5 ATPase family, AAA domain containing 5
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
FBXO4 F-box protein 4
FLT3 fms-related tyrosine kinase 3
FOXO3 forkhead box O3
GNMT glycine N-methyltransferase
HMGN1 high mobility group nucleosome binding domain 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IQGAP2 IQ motif containing GTPase activating protein 2
KRAS Kirsten rat sarcoma viral oncogene homolog
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MET MET proto-oncogene, receptor tyrosine kinase
MSH2 mutS homolog 2
NOTCH1 notch 1
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RINT1 RAD50 interactor 1
STK11 serine/threonine kinase 11
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUSC2 tumor suppressor candidate 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase