increased bone mineral density Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size (Mammalian Phenotype Ontology, MP_0000062)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000062
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Genes

78 gene mutations causing the increased bone mineral density phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACP5 acid phosphatase 5, tartrate resistant
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
ALOX5 arachidonate 5-lipoxygenase
AMER1 APC membrane recruitment protein 1
ANKH ANKH inorganic pyrophosphate transport regulator
ANXA1 annexin A1
APOE apolipoprotein E
ARSB arylsulfatase B
BMP3 bone morphogenetic protein 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
CALCB calcitonin-related polypeptide beta
CALCR calcitonin receptor
CAMK4 calcium/calmodulin-dependent protein kinase IV
CD14 CD14 molecule
CLCN7 chloride channel, voltage-sensitive 7
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
CSF1R colony stimulating factor 1 receptor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
DCSTAMP dendrocyte expressed seven transmembrane protein
DDHD1 DDHD domain containing 1
DLL1 delta-like 1 (Drosophila)
DOPEY2 dopey family member 2
ESR1 estrogen receptor 1
FKBP11 FK506 binding protein 11, 19 kDa
FOXN1 forkhead box N1
FRZB frizzled-related protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GHRHR growth hormone releasing hormone receptor
HAT1 histone acetyltransferase 1
HDAC6 histone deacetylase 6
IDUA iduronidase, alpha-L-
IFT80 intraflagellar transport 80
IL20RA interleukin 20 receptor, alpha
IL6ST interleukin 6 signal transducer
JDP2 Jun dimerization protein 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LECT1 leukocyte cell derived chemotaxin 1
LRRK1 leucine-rich repeat kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MLEC malectin
MSTN myostatin
MYO1C myosin IC
NBR1 neighbor of BRCA1 gene 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
PHOSPHO1 phosphatase, orphan 1
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYY peptide YY
PZP pregnancy-zone protein
RGS10 regulator of G-protein signaling 10
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAP47 synaptosomal-associated protein, 47kDa
SOST sclerostin
SPNS2 spinster homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
TBC1D2B TBC1 domain family, member 2B
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TMEM64 transmembrane protein 64
TNF tumor necrosis factor
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TYROBP TYRO protein tyrosine kinase binding protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XYLB xylulokinase homolog (H. influenzae)