increased bone mass Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an increase in the total amount of bone tissue contained in the skeleton (Mammalian Phenotype Ontology, MP_0005605)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005605
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Genes

64 gene mutations causing the increased bone mass phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
BGLAP bone gamma-carboxyglutamate (gla) protein
CALCR calcitonin receptor
CD14 CD14 molecule
CLCN7 chloride channel, voltage-sensitive 7
COL1A1 collagen, type I, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTSK cathepsin K
DCSTAMP dendrocyte expressed seven transmembrane protein
ESRRA estrogen-related receptor alpha
FERMT3 fermitin family member 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB2 GRB2-associated binding protein 2
GCM2 glial cells missing homolog 2 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HCST hematopoietic cell signal transducer
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
JDP2 Jun dimerization protein 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KL klotho
LEP leptin
LRP5 low density lipoprotein receptor-related protein 5
LRRK1 leucine-rich repeat kinase 1
LTBP3 latent transforming growth factor beta binding protein 3
MATN3 matrilin 3
MC4R melanocortin 4 receptor
MITF microphthalmia-associated transcription factor
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
NBR1 neighbor of BRCA1 gene 1
NFE2 nuclear factor, erythroid 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOS2 nitric oxide synthase 2, inducible
OSTM1 osteopetrosis associated transmembrane protein 1
PER1 period circadian clock 1
PGR progesterone receptor
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNA1 plexin A1
PPARG peroxisome proliferator-activated receptor gamma
SBNO2 strawberry notch homolog 2 (Drosophila)
SIGLEC15 sialic acid binding Ig-like lectin 15
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOST sclerostin
SPI1 Spi-1 proto-oncogene
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THRA thyroid hormone receptor, alpha
TLR4 toll-like receptor 4
TMEM64 transmembrane protein 64
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOB1 transducer of ERBB2, 1
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TYROBP TYRO protein tyrosine kinase binding protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor